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It has been known since 1978 that B6 depletion by peripheral carbidopa depletes central dopamine by compromising the B6 enzyme AADC, 41 an event that induces PD reversible symptom deterioration and facilitates irreversible PN

The published research base is entirely preclinical (rat and mouse studies plus rat hippocampal neuron culture work)

Up to two to four weeks in most individual And two three to six months in I would say 99 of the people they see some improvement in their health and wellness and they're most of them are working with the physicians So they're doing some blood tests before and after the doctors are saying what the heck you're doing I don't know what you're doing, but keep on doing it

Park H1, Poo MM